WebSep 25, 2024 · For the ‘ground truth’ model (predicting drug sensitivity in NCI60 from drug sensitivity in CTRP for shared cell lines and compounds), the dose–response AUC values from the CTRP screen were used. Cell viability assay PC3 and VCaP cell lines were purchased from ATCC. WebApr 11, 2024 · HIGHLIGHTS. who: (TME et al. from the of Southern California, United Statescombination of the University of California Santa Cruz (UCSC) database, Cancer have published the research: Systematic pan-cancer analysis of the potential tumor diagnosis and prognosis biomarker P4HA3, in the Journal: (JOURNAL) what: The authors evaluated …
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WebJan 6, 2024 · To analyze the cellular response of the cancer cell lines to specific therapeutic drugs, we used the Cancer Treatment Response Portal (CTRP), which covered the link between compound sensitivity and genetic or lineage … WebMay 11, 2024 · 该数据库基于多个研究与数据库信息,整合并重新分析,从细胞、药物和分子三个检索层次,阐述了不同肿瘤细胞对药物的敏感度和反应。 GDSC主要包括三个方面的数据: 1. 药物敏感性基因特征分析;2. 细胞系药物敏感性数据;3. 细胞系的基因组突变与CNV变异数据,表达谱数据以及甲基化数据(GSE68379);其中,2024年2月的8.2更新 … simple boards
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WebAug 9, 2016 · We developed a new drug sensitivity metric, the area under the dose response curve adjusted for the range of tested drug concentrations, which allows … WebMay 31, 2024 · EDDY has been used in conjunction with the Cancer Therapeutics Response Portal (CTRP), a dataset with drug-response measurements for more than 400 small molecules, and RNAseq data of cell lines in the Cancer Cell Line Encyclopedia (CCLE) to find potential drug-mediator pairs. WebThe Cancer Therapeutics Response Portal (CTRP) bridges genetic, genealogical, and other cellular characteristics of cancer cell lines with small-molecule sensitivity to support future patient-matched drug discovery based on predictive biomarkers. 36 The Genomics of Drug Sensitivity in Cancer (GDSC) database characterizes 1,000 human cancer cell ... simple blush wedding gowns