Web6 apr. 2024 · rPFS was longer in the combination arm with median rPFS of 21.3 months for enzalutamide versus 24.3 months for enzalutamide plus abiraterone acetate and prednisone (HR 0.86; two-sided p = 0.02). However, pharmacokinetic clearance of abiraterone acetate was 2.2- to 2.9-fold higher when administered with enzalutamide, compared with … Web7 apr. 2024 · B-cell lymphoma 6 (BCL6) is a transcriptional repressor and oncogenic driver of diffuse large B-cell lymphoma (DLBCL). Here, we report the optimization of our previously reported tricyclic quinolinone series for the inhibition of BCL6. We sought to improve the cellular potency and in vivo exposure of the non-degrading isomer, CCT373567, of our …
Metabolic Biomarkers in B-Cell Lymphomas for Early Diagnosis …
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Diffuse Large B-Cell Lymphoma NEJM
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