Imp-1/crd-bp function

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Witryna25 maj 2007 · CRD-BP/IMP-1 expression in HCT116 colon cancer cells (a) and adult human colon (b–e).Immunohistochemistry was performed as described in the Material and methods section by either using a rabbit anti-CRD-BP/IMP1 antibody (a and e), or by using a goat anti CRD-BP/IMP-1 antibody (b–d).In normal mucosa (b, d, e) CRD … Witryna4 cze 2007 · The probability of differences in overall survival as a function of time was determined by Kaplan–Meier test, with probing for significance by applying log-rank …

IGF2BP1 - Wikipedia

WitrynaCRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper … Witryna10 paź 2016 · CRD-BP, the coding region determinant binding protein, also known as insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1 or IGF2BP-1), is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, and localization. curmudgeons crossword

C‐MYC and IGF‐II mRNA‐binding protein (CRD‐BP/IMP‐1) …

Witryna29 sie 2024 · Introduction. Insulin-like growth factor II mRNA-binding protein 1 (IGF2BP1/IMP1), also known as the c-Myc coding region determinant-binding protein (CRD-BP) and zipcode-binding protein 1 (ZBP1), is a multifunctional RNA-binding protein that binds to diverse cancer-associated mRNAs to promote mRNA stability, … Witryna25 maj 2007 · CRD-BP/IMP-1 expression in HCT116 colon cancer cells (a) and adult human colon (b–e).Immunohistochemistry was performed as described in the Material and methods section by either using a rabbit anti-CRD-BP/IMP1 antibody (a and e), or by using a goat anti CRD-BP/IMP-1 antibody (b–d).In normal mucosa (b, d, e) CRD … Witryna15 cze 2006 · CRD-BP function seems to be important for the pathogenesis. of human colorectal cancer, a disease in which the activation of. b ... (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. Int. J. curmudgeonliness meaning

Transcriptional Regulation of CRD-BP by c-myc: Implications for c …

Witryna19 lis 2004 · CRD-BP/IMP-1 is highly related to IMP-2 and IMP-3, which together comprise a family of proteins that bind to the 5′-untranslated region of IGF-II leader 3 mRNA. ... In summary, our results revealed a novel function for CRD-BP in cell proliferation involving an IGF-II-dependent mechanism that appears independent of … WitrynaHere, we confirm that human CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in cell lines of neoplastic origin and in selected primary tumors. In a series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%, respectively, were … curmudgeonly and skeptical blogspotWitrynapreferentially to distinct CRD-BP KH domains. The novel insights revealed in this study have important implications on the understanding of the oncogenic mechanism of CRD-BP a well as in the future design of inhibitors against CRD-BP function. Coding region determinant-binding protein (CRD-BP; mouse), also known as IMP1 (human), curmudgeonly definition english

"WitrynaPlasmid pMSCV PIG IMP-1-long-mut from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, … " - Imp-1/crd-bp function

Imp-1/crd-bp function

IMP-1 Recombinant Protein - Cat. No. 39-901 ProSci

WitrynaDownload scientific diagram siRNA-mediated reduction of CRD-BP/IMP1 mRNA levels . A, efficiency of siRNA uptake by MCF-7 cells. MCF-7 cells were transfected with a control non-silencing ... Witryna7 sty 2011 · CRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper cell adhesion, cytoplasmic spreading, and invadopodia formation through its binding to the 3′UTR of CD44 mRNA and stabilization of the mRNA. In …

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WitrynaPlasmid pIS1 IMP-1 long UTR from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 UTR and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1) ... Long means that all functional alternative polyadenylation signals have been deleted. WitrynaIMP-1 Recombinant Protein (Cat. No. 39-901) has been validated for use in E and WB. ... ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1, Insulin-like growth factor 2 mRNA-binding …

Witryna9 kwi 2024 · CRD-BP has a dominant role in proliferation of human K562 cells by an IGF-II-dependent mechanism independent of its ability to serve as a c-myc … Witryna5 maj 2008 · Inhibition of β-TrCP function sensitizes human ... (2001). C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. ... (2007). CRD-BP shields c-myc and ...

Witryna19 lis 2004 · Thus, we have identified a dominant function for CRD-BP in cell proliferation of human K562 cells, involving a possible IGF-II-dependent mechanism … WitrynaInsulin -like growth factor II mRNA-binding protein, CRD-BP, VICKZ1), IMP-2 (IMP2, VICKZ2, p62) and IMP-3 (KOC1, VICKZ3), contain a unique combination of RNA recognition motifs and four hnRNP K homology domains. IMP-1 is abundant in embryonal tissues and in 81% of colon cancers, 58.5% of breast

WitrynaPlasmid pMSCV PIG IMP-1-long-mut from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1) ... Long means that all functional alternative polyadenylation signals have been deleted.

Witryna9 paź 2013 · High levels of CRD-BP that are found in primary human colorectal tumours exhibiting active beta-catenin/Tcf signalling implicates CRD-BP induction in the upregulation of beta TrCP1, in the ... curmudgeon lyricsWitrynaprotein. CRD-BP was later shown to be identical to IMP-1 (14, 19). CRD-BP/IMP-1 is highly related to IMP-2 and IMP-3, which together comprise a family of proteins that … curmudgeon meaning imagesWitrynaUpper panel, analysis by gel electrophoresis of CRD-BP/IMP1 amplicons. 1, BM CD34 cells cultured in plain medium; 2, medium containing 5azaC; 3, medium containing the cytokines mixture; 4, medium ... curmudgeon red wineWitrynaIGF2BP1. Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene. [5] [6] [7] This gene encodes a member of the IGF … curmudgeons attributeWitrynaIMP-1 Recombinant Protein (Cat. No. 39-901) has been validated for use in E and WB. ... ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1, Insulin-like growth factor 2 mRNA-binding protein 1, Coding region determinant ... The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". cookielawinfo … curmudgeonly meansThe mouse Coding Region Determinant-Binding Protein (CRD-BP) is an RNA-binding protein. CRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ZBP1 and the human forms of the protein IMP-1, IMP-2 and IMP-3. Because of their close … Zobacz więcej CRD-BP is a 577 amino acid protein that contains 4 KH domains, 2 RRMs and a RGG box (Figure 2). CRD-BP and human IMP-1 are not identical but shows a high degree of resemblance. They are very closely related … Zobacz więcej CRD-BP and its orthologs have been shown to have the ability to bind CD44, beta-actin, c-myc, IGF2, H19 and tau RNA transcripts. CRD-BP has been shown to play a crucial role in cancer growth and invasion of tissues. CD44 proteins belong to a family of … Zobacz więcej curmudgeons synonymWitrynaPlasmid pMSCV PIG IMP-1-short from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... Function; Biosensors; Chemogenetics; … curmudgeons day