Trim37 and plk4

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August undefined, 2024

WebSep 9, 2024 · TRIM37 prevents PLK4 condensation We next investigated why reducing TRIM37 levels improves acentrosomal mitosis, whereas increasing TRIM37 levels … WebJun 27, 2024 · We found that TRIM37 is a key mediator of growth arrest after partial or full PLK4 inhibition. Interestingly, PLK4 cellular mobility decreased in a dose-dependent manner after centrinone B treatment. In contrast to recent work, we found that growth arrest after PLK4 inhibition correlated better with PLK4 activity than with mitotic length or ...

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WebJun 27, 2024 · selective PLK4 inhibitor. We found that TRIM37 is a key mediator of growth arrest after partial or full PLK4 inhibition. Interestingly, PLK4 cellular mobility decreased in a dose- dependent... WebMay 7, 2024 · These data provide insights into the global response to changes in centrosome number and PLK4 activity and extend the role for TRIM37 in regulating the abundance, localization and function of centrosome proteins. ### Competing Interest Statement The authors declare that DD is a shareholder of Repare Therapeutics and DD … plaster skimming a wall

TRIM37: a critical orchestrator of centrosome function

WebNov 2, 2024 · TRIM37 exerted bidirectional control over mitosis in PLK4-inhibited cells. Whereas TRIM37 overexpression led to catastrophic mitotic failure in cells treated with a … WebJun 27, 2024 · Our results confirmed that PLK4 and TRIM37 form a complex in RPE-1 cells (Meitinger et al., 2024). Further, the region from amino acids 505–709 of TRIM37 was … WebFor details on statistics, see Methods; unpaired t-tests assuming equal standard deviation were performed. from publication: TRIM37 controls cancer-specific vulnerability to PLK4 … plaster skimming pricing

TRIM37 tripartite motif containing 37 [ (human)] - National Center …

Abstract 4998: Selective PLK4 inhibition demonstrates synthetic ...

WebThe Opeongo Bowldrome Ltd. is located at 233 Raglan St. S. and offers league bowling, open bowling, birthday/corporate parties and indoor golf. WebJan 25, 2024 · A number of centrosome-related TRIM37 functions have been described. In the absence of TRIM37, a collection of centriole proteins such as CNTROB, PLK4, CETN1/2, CP110 accumulate to form... plaster soffitWebMar 14, 2024 · Additionally, selective PLK4 inhibition induced significantly greater apoptosis in a caspase 3/7 assay in TRIM37 high cancer cells vs other cells. In a PLK4 stabilization assay, a measure of... plaster solutions

"WebLoss of function mutations in the E3 ubiquitin ligase TRIM37 result in MULIBREY nanism, a disease characterized by impaired organ growth and a high propensity to develop different tumor types. Additionally, increased copy number of TRIM37 is a feature of some breast cancers and neuroblastomas. ... including Centrobin-PLK4 assemblies, which can ... " - Trim37 and plk4

Trim37 and plk4

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WebJan 16, 2024 · The polo family serine threonine kinase Plk4 has been proposed as a therapeutic target in advanced cancers based on increased expression in primary human cancers, facilitation of tumor growth in murine xenograft models, and centrosomal amplification induced by its overexpression. WebAug 5, 2024 · TRIM37 amplification has been observed in a large number of cancers, and synthetic lethality of PLK4 inhibitors in TRIM37-amplified breast cancer, which accounts for approximately 10% of breast cancers, has been confirmed [18, 19]. Therefore, inhibition of PLK4 using PLK4 small-molecule inhibitors provides a new approach to trigger selective ...

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WebAug 5, 2024 · Serine/threonine-protein kinase polo-like kinase 4 (PLK4) is a mitosis-associated protein kinase that plays a vital role in the duplication of centrioles in dividing cells and is considered a promising target of synthetic lethality in TRIM37-amplified breast cancer. Herein, based on a rational drug … WebJul 1, 2024 · TRIM37 deletion restored the ability of cells to proliferate in centrinone. Thus, centrosome removal via Plk4 inhibition appears to be a promising strategy for therapeutic treatment of neuroblastomas and potentially other …

WebSep 18, 2024 · When TRIM37 is more active, centrosomes do not behave correctly and errors occur during cell division, leading to the overactive cell division that results in tumors. 1 An enzyme called PLK4 kickstarts the errant cell division process in … Weba．在 plk4 的正常调控下，中心体在每个细胞周期的间期复制一次: b．plk4 失活后，非中心体型纺锤体组装取决于 trim37 的水平: c．在 plk4 失活的情况下，trim37 基因过度表达可促使癌细胞分裂: d．在 trim37 基因过度表达的细胞中可能观察到染色体数目加倍

Web豆丁网是面向全球的中文社会化阅读分享平台，拥有商业,教育,研究报告,行业资料,学术论文,认证考试,星座,心理学等数亿实用 ... WebTRIM37 controls cancer-specific vulnerability to PLK4 inhibition. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. TRIM37 has a role in …

WebJan 25, 2024 · TRIM37 regulates the stability and solubility of Centrobin, which accumulates in elongated entities resembling the striped electron dense structures upon TRIM37 depletion. Furthermore, Cenpas formation upon TRIM37 depletion requires PLK4, as well as two parallel pathways relying respectively on Centrobin and PLK1.

WebSep 9, 2024 · Extended Data Fig. 2 Inhibitor selectivity for PLK4—and not other kinases—is required for the synthetic lethal killing of cells overexpressing TRIM37. a, Representative … plaster solutions limitedWebSep 10, 2024 · “The idea would be to identify tumors with high levels of TRIM37 and use a PLK4 inhibitor to selectively kill cancer cells and leave healthy cells relatively unharmed,” explained Holland. The... plaster siding for housesWebSep 17, 2024 · Low TRIM37 levels accelerate acentrosomal spindle assembly and improve proliferation following PLK4 inhibition, whereas high TRIM37 levels inhibit acentrosomal … plaster slip mold castingWebTo assess if elevated TRIM37 expression in cancers confers enhanced sensitivity to PLK4 inhibition, we analyzed two breast cancer (BT474 and MCF7) and four neuroblastoma … plaster solutions sheffieldWebApr 4, 2024 · Request PDF Abstract 4998: Selective PLK4 inhibition demonstrates synthetic lethality in TRIM37 amplified neuroblastoma and breast cancer models while less selective inhibitors do not ... plaster splint cptWebThe PLKs comprise a protein family that has been identified as critical for spindle formation (26), centrosome duplication (27), and mitotic entry (28). PLK4 is the most structurally... plaster slump molds for clayWebPrice. Beds. Bath. Sqft. There are currently 39 Real Estate Listings & Homes for Sale in Renfrew, ON. The average listing price for Renfrew homes on Ovlix.com $558,935. … plaster splint cast